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目的观察具有滋补肝肾、通络解毒功效中药熟地平颤汤结合西医常规疗法治疗帕金森病的临床疗效。方法采用多中心、随机对照的方法 ,将120例病例随机分为治疗组和对照组各60例。对照组继续原有西药治疗,治疗组同时加用熟地平颤汤和蝎蜈胶囊,两组疗程均为3个月;观察两组临床疗效及治疗后帕金森病统一评分量表(UPDRS)第二分量表(运动功能判断)和第三分量表(病程中疾病发展程度的判断)评分、改良的Hoehn&Yahr分级、左旋多巴用量、“开关”现象变化情况。结果治疗组和对照组总有效率分别为43.33%、16.67%;组间疗效比较,差异有统计学意义(P<0.01)。治疗组可明显改善患者的运动症状,减少UP-DRS II(P<0.05)和UPDRS III(P<0.01)评分;对有开关现象者可延长开期时间,减少关期时间(P<0.05),而且未见明显毒副作用。结论熟地平颤汤结合西医常规疗法治疗帕金森病具有增效减毒作用。
Objective To observe the clinical efficacy of nourishing the liver and kidney and clearing the channels and detoxifying the traditional Chinese medicine, Rehmanniae Treating Parkinson’s disease in combination with Western conventional therapy. Methods A multicenter, randomized controlled trial of 120 cases was randomly divided into treatment group and control group of 60 cases. The control group to continue the treatment of the original Western medicine, the treatment group also added Rehmannia Trepang Decoction and scorpion centipede capsules, two courses of treatment were 3 months; observed two groups of clinical efficacy and treatment of Parkinson’s Disease Uniform Rating Scale (UPDRS) Dichotomous scale (judgments of motor function) and the third subscale (judgment of degree of disease progression in the course of disease), modified Hoehn & Yahr grade, levodopa dosage, and “switch” phenomenon. Results The total effective rates of the treatment group and the control group were 43.33% and 16.67% respectively. There was significant difference between the two groups (P <0.01). The treatment group can significantly improve the patient’s motor symptoms, reduce the UP-DRS II (P <0.05) and UPDRS III (P <0.01) scores; patients with switch can extend the open time and reduce the off-time (P < , But no obvious side effects. Conclusion Rehmannia Treplet Decoction combined with conventional Western medicine treatment of Parkinson’s disease with synergistic effect attenuated.