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目的探讨维吾尔药异常黑胆质成熟剂对维吾尔族异常黑胆质型乳腺癌患者放疗后T细胞及自然杀伤(NK)细胞的影响趋势。方法对40例维吾尔族异常黑胆质型乳腺癌患者放疗前后分别用流式细胞仪检测T细胞及NK细胞水平,并随机分为药物干预组和对照组,比较2组T细胞亚群及NK细胞的分布特点。结果药物干预组及对照组放疗前一般临床资料及T细胞、NK细胞水平差异均无统计学意义;对照组放疗前后比较发现:放疗后CD4+、CD4+/CD8+、NK明显均低于放疗前(P<0.05),药物干预组放疗后CD4+、NK高于放疗前,差异均有统计学意义(P<0.05)。结论异常黑胆质成熟剂可明显改善异常黑胆质型乳腺癌患者放疗导致的细胞免疫功能低下,具有放射防护作用。
Objective To investigate the influence of abnormal savda of Uighur herbs on T cells and natural killer (NK) cells in patients with abnormal Savda after breast cancer. Methods T cell and NK cell levels were measured by flow cytometry before and after radiotherapy in 40 Uygur patients with abnormal savda-type breast cancer and randomly divided into two groups: drug-intervention group and control group. T-cell subsets and NK The distribution of cells. Results There was no significant difference in the levels of T cells and NK cells before and after radiotherapy in the intervention group and the control group. The levels of CD4 +, CD4 + / CD8 + and NK in the control group before and after radiotherapy were significantly lower than those before radiotherapy (P <0.05). The levels of CD4 + and NK in the drug intervention group after radiotherapy were significantly higher than those before radiotherapy (P <0.05). Conclusion Abnormal savda mature agent can significantly improve the radiosensitization caused by radiotherapy in patients with abnormal savda breast cancer.