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目的:探讨改良长方案的临床应用价值。方法:回顾性分析行IVF/ICSI-ET助孕治疗的改良长方案752个取卵周期,并以常规长方案538个取卵周期为对照,比较移植周期的一般资料和临床结局,分析改良长方案的卵巢低反应发生率及其助孕治疗结局。结果:改良长方案的妊娠率、种植率、活产率高,流产率低,与常规长方案组相比有显著统计学差异(P<0.05);比较卵巢低反应周期,2种方案的卵巢低反应发生率无统计学差异(P>0.05);改良长方案的低反应组Gn使用剂量大,使用时间长,但获卵数、移植周期取消率、流产率与常规长方案无统计学差异,而妊娠率、种植率、活产率均高于长方案,差异有显著统计学意义(P<0.05)。结论:与常规长方案相比,改良长方案卵巢低反应发生率无明显增高,临床结局优于常规长方案。
Objective: To explore the clinical value of modified long protocol. Methods: A retrospective analysis of 752 cycles of ovulation induction with IVF / ICSI-ET assisted pregnancy was conducted. 538 ovulation cycles of routine long-term regimen were used as control. The general data and clinical outcomes of the transplantation cycle were compared. The incidence of ovarian response and its pregnancy-assisted treatment outcome. Results: The pregnancy rate, implantation rate, high live birth rate and low abortion rate of the long regimen were significantly different from those of the long regimen group (P <0.05). Compared with the low ovarian response period, the two regimens of ovary There was no significant difference in the incidence of low response (P> 0.05). The Gn dose of long-term modified low-response group was longer than that of conventional long-term regimen , While the pregnancy rate, planting rate and live birth rate were higher than the long-term plan, the difference was statistically significant (P <0.05). CONCLUSION: Compared with the conventional long-term regimen, the incidence of ovarian hyporesponsiveness in the modified long regimen is not significantly increased, and the clinical outcome is superior to the conventional long regimen.