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探讨复方猫爪草水提物抗急性炎症的作用 ,结果表明 :对二甲苯所致小鼠耳肿胀 ,对醋酸引起的小鼠腹腔毛细血管通透性增加 ,对蛋清所致大鼠足跖肿胀均有明显的抑制作用。提示复方猫爪草水提物的抗急性炎症作用显著 ,可能是通过抑制毛细血管的扩张 ,降低通透性 ,使渗出液减少以达到抗炎作用。复方猫爪草水提物的最大耐受量 132 g生药 / kg以上 ,相当于成年人 (5 0 kg)日剂量 0 .45 6 g生药 / kg的 2 89倍 ,提示该药急性毒性低 ,口服给药安全。
To investigate the anti-inflammation effect of compound cat’s paw water extract. The results showed that the mouse ear swelling caused by p-xylene increased acetic acid-induced capillary permeability of the abdominal cavity in mice and the swelling of the paw in rats caused by egg white. All have significant inhibitory effects. It is suggested that the anti-acute inflammation effect of the aqueous extract of the compound cat’s claw grass is significant, it may be through inhibiting the expansion of the capillaries, reducing the permeability, and reducing the exudate to achieve the anti-inflammatory effect. The maximum tolerated dose of compound cat’s claw grass water extract was 132 g crude drug/kg, which was equivalent to 2 89 times the daily dose of adult adults (50 kg) of 0. 45 6 g crude drug/kg, suggesting that the drug had low acute toxicity. Oral administration is safe.