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非均匀组织等效水厚度修正是研究质子放射治疗的重要组成部分,利用蒙特卡罗Fluka2011.2程序模拟了不同能量(50—250MeV)的质子束入射到不同介质中的输运过程,总结出了在不同介质中质子束初始能量与质子束Bragg峰深度关系,并拟合出质子束在介质中的等效水厚度修正公式.结果表明,对不同能量的质子束入射到非均匀组织中,通过拟合公式计算出Bragg峰深度值与Fluka模拟的质子束Bragg峰的位置相差在1mm之内.如果建立起介质和水的Bragg峰比与电子密度比关系的数据库,该公式有可能用于临床上的质子放射治疗的剂量计算中.
Non-uniform tissue equivalent water thickness correction is an important part of proton radiation therapy. Monte Carlo Fluka2011.2 program was used to simulate the transport process of proton beams with different energy (50-250MeV) into different media, The relationship between the proton beam initial energy and the Bragg peak depth of the proton beam in different media was fitted and the equivalent water thickness correction formula of the proton beam in the media was fitted.The results show that when the proton beam with different energy is incident on the heterogeneous tissue, The fitting of the Bragg peak depth to the position of the Fluka-simulated proton beam Bragg peak is within 1 mm by fitting the equation.If a database of Bragg peak to electron density ratios for the medium and water is established, the formula is likely to be used The dose of clinical proton radiation therapy is calculated.