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为探讨重铬酸钾导致卵黄囊功能紊乱的机理，以１，６二苯１，３，５已三烯（ Ｄ Ｐ Ｈ）为荧光探针，用荧光偏振技术观察重铬酸钾对大鼠卵黄囊细胞膜脂质流动性的影响。结果表明：重铬酸钾浓度为１０ ｍ ｇ／ Ｌ以上时，卵黄囊细胞膜脂质流动度（ Ｌ Ｆ Ｕ）降低（ Ｐ＜ ００５），胚胎发育受到抑制（ Ｐ＜ ００５），且都呈明显的剂量效应关系。提示卵黄囊细胞膜脂质流动度改变可能是重铬酸钾对大鼠胚胎发育毒性的机理之一。
In order to explore the mechanism of yolk sac dysfunction caused by potassium dichromate, 1,6 Dibenzopyridine 1,3,5-hexatriene (D P H) was used as fluorescent probe to observe the effect of potassium dichromate Effects on lipid fluidity of rat yolk sac cell membrane. The results showed that when the concentration of potassium dichromate was over 10 g / L, the cell membrane lipid fluidity (L F U) of yolk sac decreased (P <005) and the embryo development was inhibited (P <005 ), And all showed obvious dose-effect relationship. Tip yolk sac cell membrane lipid fluidity changes may be one of the mechanisms of potassium dichromate rat embryonic development.