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目的:明确亚临床甲状腺功能异常症候群患者体内血糖、血脂和尿酸水平变化情况及影响因素。方法:选取2013年6月至2015年6月我院收治的200例亚临床甲状腺功能异常患者作为研究对象,亚临床甲亢(A组)及甲减(B组)各100例,并选取健康者100例作为对照组;测定受试者血清中TSH、FT3、FT4、HDL、LDL、TC、TG、空腹血糖、UA水平;分析诸因素相关性和影响血糖及血脂的因素。结果:血清HDL水平A组较对照组显著升高(P<0.05),UA水平显著降低(P<0.05);B组患者血清中TC水平及UA水平显著升高(P<0.05);B组患者血清中FPG水平及T4水平呈明显负相关(P<0.05),FPG、HDL与FT3分别呈负相关及正相关(P<0.05);A组患者血清中HDL与FT3水平呈显著正相关关系(P<0.05);吸烟为导致TG异常的显著性影响因素(P<0.05)。结论:亚临床甲状腺功能异常患者多伴有血脂水平异常,且部分甲状腺功能指标与之相关,而吸烟则是诱发患者功能异常的主要危险性因素。
Objective: To clarify the changes of blood glucose, blood lipid and uric acid levels in patients with subclinical thyroid dysfunction syndrome and its influencing factors. Methods: A total of 200 patients with subclinical thyroid dysfunction admitted to our hospital from June 2013 to June 2015 were enrolled in this study. 100 cases of subclinical hyperthyroidism (group A) and hypothyroidism (group B) 100 cases were taken as the control group. The levels of serum TSH, FT3, FT4, HDL, LDL, TC, TG, fasting blood glucose and UA in the serum of the subjects were determined. The correlations among various factors and the factors influencing blood glucose and blood lipid were analyzed. Results: Serum HDL level in group A was significantly higher than that in control group (P <0.05), and UA level was significantly lower (P <0.05). Serum levels of TC and UA were significantly increased in group B (P <0.05) There was a significant negative correlation between serum FPG level and T4 level (P <0.05), but FPG, HDL and FT3 were negatively correlated with each other (P <0.05). There was a significant positive correlation between serum HDL and FT3 level (P <0.05). Smoking was the most significant factor leading to TG abnormality (P <0.05). Conclusions: Patients with subclinical thyroid dysfunction often have abnormal blood lipid levels, and some thyroid function indexes are related to them. Smoking is the main risk factor for inducing functional abnormalities in patients.