The excess deposition of underlying extracellular matrix(ECM)in adipose tissue is defined as adipose tissue fibrosis that is a major contributor to metabolic disorder such as obesity and type 2 diabetes.Anti-fibrosis therapy has received much attention in
Tubulointerstitial inflammation plays an important role in the progression of diabetic nephropathy(DN),and tubular epithelial cells(TECs)are crucial promoters of the inflammatory cascade.Exchange protein activated by cAMP(Epac)has been shown to suppress t
Diabetic kidney disease(DKD)is one of the microvascular complications of diabetes mellitus and a major cause of end-stage renal disease with limited treatment options.Wogonin is a flavonoid derived from the root of Scutellaria baicalensis Georgi,which has
The PTEN/AKT/mTOR signaling pathway is frequently dysregulated in non-small cell lung cancer(NSCLC),but the mechanisms are not well-understood.The present study found that the ubiquitin ligase TRIM25 is highly expressed in NSCLC tissues and promotes NSCLC
Checkpoint kinase 1 inhibitors(CHK1 i)have shown impressive single-agent efficacy in treatment of certain tumors,as monotherapy or potentiators of chemotherapy in clinical trials,but the sensitive tumor types and downstream effectors to dictate the therap
Immune checkpoint blockade has shown significant clinical benefit in multiple cancer indications,but many patients are either refractory or become resistant to the treatment over time.HER2/neu oncogene overexpressed in invasive breast cancer patients asso
Androgen receptor(AR),a ligand-activated transcription factor,is a master regulator in the development and progress of prostate cancer(PCa).A major challenge for the clinically used AR antagonists is the rapid emergence of resistance induced by the mutati
Treatment with aprotinin,a broad-spectrum serine protease inhibitor with a molecular weight of 6512 Da,was associated with acute kidney injury,which was one of the reasons for withdrawal from the market in 2007.Inhibition of renal serine proteases regulat
Metabolic-associated fatty liver disease(MAFLD)is the most common metabolic disease with a global prevalence of 25%.While MAFLD is serious and incurable at the later stage,it can be controlled or reversed at the early stage of hepatosteatosis originating
Individual differences in the development of uncontrollable fear in response to traumatic stressors have been observed in clinic,but the underlying mechanisms remain unknown.In the present study we first conducted a meta-analysis of published clinical dat