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[目的]探讨罗格列酮联合卡托普利治疗早期糖尿病肾病（DN ）的疗效。[方法]入住本院的DN患者80例，随机分为观察组和对照组各40例，在给予降糖药二甲双胍控制血糖后，分别给予罗格列酮联合卡托普利治疗及单纯卡托普利治疗，观察两组治疗后空腹血糖（FPG）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-D）、低密度脂蛋白胆固醇（LDL-C）、尿微量蛋白（mAlb）、收缩压（SBP）、舒张压（DBP）变化。[结果]两组患者治疗后 mAlb、FPG、TC、LDL-C、SBP、DBP均较治疗前显著下降（ P ＜0．05）；观察组mA1b、FPG下降较对照组更为显著（ P ＜0．05）。对照组和观察组在治疗中分别出现1例和2例双下肢踝部轻度水肿。[结论]罗格列酮联合卡托普利治疗早期DN疗效较好，且使用安全。“,”[Objective]To explore the efficacy of rosiglitazone combined with captopril for the treatment of early diabetic nephropathy(DN) .[Methods]A total of 80 DN patients were randomly divided into observation group and control group with 40 patients in each group .After given metformin to control blood sugar ,two groups received only captopril or combined with rosiglitazone ,respectively .Fasting blood glucose(FPG) ,total cholesterol(TC) ,triglycerides(TCT) ,high-density lipoprotein cholesterol(HDL-C) ,low-density lipoprotein cholesterol(LDL-C) ,urine protein(mAlb) ,systolic blood pressure(SBP) and diastolic blood pressure(DBP) after treatment were observed .[Results] Compared with before treatment ,mA1b ,FPG ,TC ,LDL-C ,SBP and DBP in two group after treatment were markedly decreased ( P <0 .05) .The mA1b and FPG in observa-tion group were decreased more significantly than those in control group ( P <0 .05) .Mild hydrops of ankles in both lower extremities was found in 1 patient of control group and 1 patient of observation group .[Conclu-sion]Rosiglitazone combined with captopril for the treatment of early DN has good efficacy and safety .