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用α-干扰素治疗慢性丙型肝炎,约有40％的病人ALT转为正常,但治疗有效的病人在停药后约50％ALT重又升高。迄今为止,尚无有关对首次治疗后无效或复发的病人用干扰素再次治疗的前瞻性研究。本研究的目的是评估用相同剂量α-干扰素再治疗首次治疗无效和复发的慢性丙型肝炎病人的效果。作者对符合下列标准的12例病人进行了再治疗:已用重组α-干扰素治疗6个月,
In patients with chronic hepatitis C treated with a-interferon, ALT turns normal in about 40% of patients, but about 50% of patients in a therapeutically effective group regain their weight again after withdrawal. To date, there is no prospective study of relapse with interferon in patients who became ineffective or relapsed after initial treatment. The purpose of this study was to evaluate the efficacy of re-treatment of patients with first-time treatment-ineffective and relapsed chronic hepatitis C with the same dose of a-interferon. The authors re-treated 12 patients who met the criteria of having been treated with recombinant interferon alpha for 6 months,