VEGF在脓毒症毛细血管渗漏中的作用

• 作 者: 刘毅 宋诗铎
• 机 构: 天津医科大学第二医院急诊科,
• 出 处: 国际内科学杂志
• 发表日期: 2009年01期
• 关键词: 血管内皮生长因子 脓毒症 毛细血管渗漏

脓毒症发病率高、病死率高、治疗费用高,是危重患者主要死亡原因之一,其根本发病机制不清。近年研究表明,微血管通透性增加是脓毒症发生发展的关键因素,而血管内皮生长因子(VEGF)是控制血管通透性的关键分子,是导致炎症相关毛细血管通透性增加的潜在因素。脓毒症早期VEGF增高,致微血管通透性增加,毛细血管渗漏,加重炎症反应,脓毒症患者普遍存在毛细血管渗漏现象。VEGF是一种细胞因子,广泛存在于机体并参与体内多种疾病过程。本文对VEGF在脓毒症中的作用机制加以综述。

The high incidence of sepsis, high mortality, high cost of treatment is one of the main causes of death in critically ill patients, the underlying pathogenesis is unclear. In recent years, studies have shown that increased microvascular permeability is a key factor in the development of sepsis, and vascular endothelial growth factor (VEGF) is a key molecule that controls vascular permeability and is a potential factor that leads to increased capillary permeability of inflammation . Early sepsis increased VEGF, microvascular permeability increased, capillary leakage, aggravating inflammation, sepsis in patients with widespread capillary leak phenomenon. VEGF is a cytokine that is widespread in the body and participates in many disease processes in the body. This article reviews the mechanism of VEGF in sepsis.