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目的探讨原发性肝癌患者血清中血管内皮生长因子(VEGF)-A、VEGF-C及白介素(IL)-8表达水平及其临床意义。方法将61例原发性肝癌分为无转移组32例(A组)、有远处转移组29例(B组)。正常对照组43例(C组)来自健康体检者。酶联免疫吸附试验测定3组血清中VEGF-A、VEGF-C及IL-8含量。结果 A组及B组患者VEGF-A、VEGF-C及IL-8均显著高于C组(P<0.01,P<0.05)。B组患者血清中VEGF-A、VEGF-C及IL-8明显高于A组(P<0.05)。结论原发性肝癌患者血清中VEGF-A、VEGF-C及L-8表达显著升高,且可能与是否发生转移有关。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) -A, VEGF-C and interleukin (IL) -8 in patients with primary liver cancer and its clinical significance. Methods 61 cases of primary liver cancer were divided into 32 cases without metastasis (group A) and 29 cases with distant metastasis (group B). 43 cases of normal control group (C group) from the health examination. Serum levels of VEGF-A, VEGF-C and IL-8 were measured by enzyme linked immunosorbent assay. Results The levels of VEGF-A, VEGF-C and IL-8 in group A and group B were significantly higher than those in group C (P <0.01, P <0.05). Serum levels of VEGF-A, VEGF-C and IL-8 in group B were significantly higher than those in group A (P <0.05). Conclusion The serum levels of VEGF-A, VEGF-C and L-8 in patients with primary liver cancer are significantly increased, and may be related to the occurrence of metastasis.