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用家兔作动物模型，观察地塞米松对膈肌功能的影响。结果表明，静注地塞米松２．５ｍｇ×７ｄ，对动物膈肌收缩力无显著影响；但可使动物膈肌耐力显著减低。实验组及对照组的耐力时间分别为２６．４±１．８ｍｉｎ及３７．４±１．８ｍｉｎ（Ｐ＜０．０５）。静注地塞米松２ｍｇ×１４ｄ后，实验组动物的膈肌收缩力及耐力均显著低于对照组。同时还发现急、慢性损伤中，动物膈肌疲劳后收缩力的恢复均不受影响。提示地塞米松对膈肌功能的影响可能有其潜在的临床意义。
Rabbits were used as animal models to observe the effect of dexamethasone on diaphragmatic function. The results showed that intravenous injection of dexamethasone 2.5mg × 7d, no significant impact on animal diaphragm muscle contractility; but can significantly reduce the animal diaphragmatic endurance. The endurance time of experimental group and control group were respectively 26.4 ± 1.8min and 37.4 ± 1.8min (P <0.05). After intravenous injection of dexamethasone 2mg × 14d, the contractility and endurance of diaphragmatic muscle in the experimental group were significantly lower than those in the control group. At the same time also found that acute and chronic injury, the recovery of the contractility of the animal diaphragm after fatigue are not affected. Tip dexamethasone on the diaphragm function may have its potential clinical significance.