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Background:Serine hydroxymethyltransferase 1(SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit.SHMT1 C1420 T may lead to the abnormal biosynthesis involved in DNA synthesis and methylation,and it may eventually increase cancer susceptibility.Many epidemiologic studies have explored the association between C1420 T polymorphism and the risk of non-Hodgkin lymphoma(NHL),but the results have been contradictory.Therefore,we performed this meta-analysis to evaluate the relationship.Methods:The meta-analyses were conducted to evaluate the effect of SHMT1 C1420 T polymorphism on NHL risk.Odds ratios(ORs) and 95%confidence intervals(Cls) were calculated to measure the strength of the association.Results:Eight studies encompassing 3232 cases and 4077 controls were included.A statistically significant association was found between SHMT1 C1420 T polymorphism and NHL risk under the allelic comparison(T vs.C:OR = 1.09,95%CI 1.01-1.17);a borderline association was found between SHMT1 C1420 T polymorphism and NHL risk under the homozygote model(TT vs.CC:OR = 1.18,95%CI 1.00-1.39) and the dominant model(CT+TT vs.CC:OR = 1.10,95%CI 1.00-1.21).Conclusion:SHMT1 C1420 T polymorphism may be associated with NHL risk,which needs to be validated in large,prospective studies.
Background: Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. SHMT1 C1420 T may lead to the abnormal biosynthesis involved in DNA synthesis and methylation, and it may eventually increase cancer susceptibility. Many epidemiologic studies have explored the association between C1420 T polymorphism and the risk of non-Hodgkin lymphoma (NHL), but the results have been contradictory.Therefore, we performed this meta-analysis to evaluate the relationship.Methods: The Met-analyzes were conducted to evaluate the effect of SHMT1 C1420 T polymorphism on NHL risk. Odds ratios (ORs) and 95% confidence intervals (Cls) were calculated to measure the strength of the association. Results: Eight studies encompassing 3232 cases and 4077 controls were included. A significant significant association was found between SHMT1 C1420 T polymorphism and NHL risk under the allelic comparison (T vs. C: OR = 1.09, 95% CI 1.01-1.17); a borderline association was found between SHMT1 C1420 T polymorphism and NHL risk under the homozygote model (TT vs. CC: OR = 1.18, 95% CI 1.00-1.39) and the dominant model (CT + TT vs. CC: OR = 1.10, 95% CI 1.00-1.21) .Conlusion: SHMT1 C1420 T polymorphism may be associated with NHL risk, which needs to be validated in large, prospective studies.