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硝喹为一种喹唑啉类抗疟药,其化学结构为2-4二氨基-6-[(3.4二氯苄其)亚硝基氨基]喹唑啉醋酸盐,国外代号为CI-679。1970年Thompson首先报道该化合物在实验室内对鼠疟、猴疟有较好的抑制作用。1979年Schmidt研究了其对猴疟的作用。但在临床上的应用迄今未见报道。1971年上海医药工业研究院合成了该化合物,第三军医大学疟疾研究组与该院协作,对其抗疟作用、药代动力学、毒性作用及安全
Quinuquine is a quinazoline antimalarial drug whose chemical structure is 2-4 diamino-6 - [(3.4 dichlorobenzyl) nitrosoamino] quinazoline acetate. The foreign code is CI- 679. In 1970, Thompson first reported that the compound has good inhibitory effect on murine malaria and malaria in the laboratory. 1979 Schmidt studied its effect on monkey malaria. However, no clinical application has been reported so far. The compound was synthesized by the Shanghai Institute of Pharmaceutical Industry in 1971 and the malaria research team of the Third Military Medical University, in collaboration with the hospital, was able to evaluate its anti-malarial effects, pharmacokinetics, toxic effects and safety