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AIM:To explore the relationship between clinical findingsof patients with chronic liver diseases and the pathologicgrading and staging of liver tissues.METHODS:The inflammatory activity and fibrosis ofconsecutive liver biopsies from 200 patients were determinedaccording to the diagnosis criteria of chronic hepatitis inChina established in 1995.A comparative analysis was carriedout for 200 patients with chronic liver diseases by comparingtheir clinical manifestations,serum biochemical marker’s withthe grading and staging of liver tissues.RESULTS:It was revealed that age,index of clinicalsymptoms and physical signs were obviously relevant to thepathologic grading and staging of liver tissues(P<0.05).Bloodplatelet,red blood cells,aspartate aminotransferase(AST),N-terminal procollagen Ⅲ(PⅢ NP)were apparently correlatedwith the degree of inflammation.PGA(prothrombin time,GGT,apoprotein A1)index,PGAA(PGA+△2-macroglobublin)index,albumin and albumin/globulin were relevant to bothinflammation and fibrosis.Hyaluronic acid(HA)was anaccurate variable for the severity of hepatic inflammationand fibrosis.The combination of serum markers for fibrosiscould increase the diagnostic accuracy.It was notable thatviral replication markers were not relevant to the degree ofinflammation and fibrosis.CONCLUSION: There is a good correlation between clinicalfindings and the pathologic grading and staging of livertissues, which may give aid to the noninvasive diagnosis of liver fibrosis.
AIM: To explore the relationship between clinical findings of patients with chronic liver diseases and the pathologicgrading and staging of liver tissues. METHHODS: The inflammatory activity and fibrosis of convulsive liver biopsies from 200 patients were determined acccording to the diagnosis criteria of chronic hepatitis in China established in 1995. A comparative analysis was carriedout for 200 patients with chronic liver diseases by comparing their clinical manifestations, serum biochemical marker’s with the grading and staging of liver tissues .RESULTS: It was revealed that age, index of clinical symptoms and physical signs were obviously relevant to thepathologic grading and staging of liver tissues (P <0.05) .Bloodplatelet, red blood cells, aspartate aminotransferase (AST), N-terminal procollagen Ⅲ (PⅢ NP) were apparently correlated with the degree of inflammation.PGA (prothrombin time, GGT, PGAA (PGA + Δ 2-macroglobublin) index, albumin and albumin / globulin were relevant to both inflama tion and fibrosis. Hyaluronic acid (HA) was anaccurate variable for the severity of hepatic inflammation and fibrosis. combination of serum markers for fibrosiscould increase the diagnostic accuracy. It was not able to detect viral replication markers were not relevant to the degree of inflamation and fibrosis. CONCLUSION: There is a good correlation between clinicalfindings and the pathologic grading and staging of livertissues, which may give aid to the noninvasive diagnosis of liver fibrosis.