The inhibitory effect of microRNA-1827 on anoikis resistance in lung adenocarcinoma A549 cells via t

• 作 者: Xuedan Guo Zhi Wang Qing Sun Chunhua Sun Hongxia Hua Qing Huang
• 机 构: Department of 0ncology, Wuxi No.2 People’s Hospital Affiliated to Nanjing Medical University, Wuxi 2
• 出 处: 生物化学与生物物理学报（英文版）
• 发表日期: 2020年10期
• 关键词: NSCLC anoikis resistance microRNA-1827 caveolin-1 A549 cell

Anoikis resistance is a critical process for cancer cell metastasis in non-small cell lung cancer (NSCLC),and microRNA-1827 (miR-1827) is closely correlated with NSCLC metastasis.In this study,we aimed to evaluate the role of miR-1827 in regulating the anoikis resistance of NSCLC.The results showed that miR-1827 level was decreased in tumor tissues and cells and was correlated with tumor grade and lymph node (LN) metastasis.Overexpression of miR-1827 inhibited anchorageindependent growth and anoikis resistance in A549 cells.Bioinformatics and functional analysis identified that caveolin-1 (CAV-1) is directly targeted by miR-1827.Restoration of CAV-1 significantly attenuated miR-1827's effect on anoikis resistance in A549 cells.Our data identified a novel signaling axis of miR-1827/CAV-1 in regulating anoikis resistance,which might serve as a potential therapeutic target for metastatic NSCLC.