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目的观察复方异丙托溴铵联合布地奈德治疗毛细支气管炎的疗效。方法采取回顾性研究方法,选择毛细支气管炎患儿100例,随机分为治疗组和对照组各50例,在综合治疗基础上,两组均常规应用布地奈德雾化液雾化吸入,0.5mg/次,2次/d;治疗组加用吸入用复方异丙托溴铵溶液雾化吸入,1.25ml/次,2次/d。结果治疗组显效率和总有效率分别为80%(40/50例)和98%(49/50例);对照组分别为46%(23/50例)和62%(31/50例),两组显效率和总有效率比较差异有显著性意义(χ2=20.77,20.25,P<0.01)。结论复方异丙托溴铵联合布地奈德治疗毛细支气管炎可有效缓解喘憋、哮鸣、咳嗽等临床表现,疗效优于单用布地奈德。
Objective To observe the curative effect of compound ipratropium bromide and budesonide on bronchiolitis. Methods A retrospective study was conducted to select 100 children with bronchiolitis and randomly divided into treatment group (50 cases) and control group (50 cases). On the basis of comprehensive treatment, both groups were given conventional inhalation of budesonide nebulization solution for 0.5 mg / time, 2 times / d; the treatment group plus inhaled compound ipratropium bromide solution inhalation, 1.25ml / time, 2 times / d. Results The effective rate and total effective rate were 80% (40/50) and 98% (49/50) in the treatment group and 46% (23/50 cases) and 62% (31/50 cases) respectively in the control group There was significant difference between the two groups in the markedly effective rate and the total effective rate (χ2 = 20.77,20.25, P <0.01). Conclusions The combination of ipratropium bromide and budesonide in the treatment of bronchiolitis can effectively relieve the clinical manifestations of asthma, wheezing and cough, which is superior to budesonide alone.