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芫花酯乙(yuanhuadine,下简称乙素)是从瑞香科植物芫花的花蕾中分离出的一种中期妊娠引产药,属二萜原酸酯类。其分子式为C_(32)H_(42)O_(10)。,结构式为: 1.药理作用 经动物实验证明,乙素具有较好的引产作用。我们选用妊娠3-5月,体重4-10kg恒河猴9只,其中7只猴子羊膜腔内分别注入0.025-5.0mg乙素醇制剂,2只猴子羊膜腔内注入等容积的溶剂作对照。结果表明,乙素给孕猴的羊膜腔内一次注射最低有效流产量为30μg/只,其对孕猴的最佳剂量在50-100μg之间,给药至流产相隔时间为
Yuanhuadine B (yuanhuadine, hereinafter referred to as B) is isolated from the buds of Daphne florum flower of a middle-pregnancy induced abortion drug, is a diterpene orthoester. Its molecular formula is C_ (32) H_ (42) O_ (10). , The structural formula is: 1. Pharmacological effects Animal experiments show that B has a better effect of induction of labor. We choose 3 to 5 months of gestation, weight 4-10kg 9 rhesus monkeys, of which 7 were injected into the amniotic membrane of monkey 0.025-5.0mg ethanolamine preparations, 2 monkeys injected into the amniotic cavity volume of solvent control. The results showed that the minimum effective intra-amniotic fluid injection of B to amniotic fluid of monkey was 30μg / bird, the best dosage for pregnant monkey was between 50-100μg, and the time between administration and abortion was