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目的:探讨乳腺癌组织中胸苷酸合成酶表达与各临床病理因素之间的关系。方法:采用免疫组织化学SP法检测经病理诊断证实的乳腺癌患者54例和健康体检者20例乳腺组织中胸苷酸合成酶的表达,并进行对比分析。结果:乳腺癌组织胸苷酸合成酶阳性表达率77.7%(43/54)高于正常乳腺组织40.0%(7/20),二者比较差异有统计学意义(P<0.05);胸苷酸合成酶表达与乳腺癌患者的年龄、肿瘤大小、淋巴结转移无关(P>0.05),与组织学分级有关(P<0.05)。结论:胸苷酸合成酶在乳腺癌组织中的表达增强可能在乳腺癌发展过程中起着重要作用。
Objective: To investigate the relationship between the expression of thymidylate synthase and clinicopathological factors in breast cancer. Methods: Immunohistochemical SP method was used to detect the expression of thymidylate synthase in 54 cases of breast cancer patients confirmed by pathological diagnosis and 20 cases of healthy subjects, and the comparative analysis was made. Results: The positive rate of thymidylate synthase in breast cancer tissues was 77.7% (43/54), which was significantly higher than that in normal breast tissues (40.0%, 7/20) (P <0.05) The expression of synthetase was not related to the age, tumor size and lymph node metastasis (P> 0.05) in patients with breast cancer, which was correlated with histological grade (P <0.05). Conclusion: The enhanced expression of thymidylate synthase in breast cancer may play an important role in the development of breast cancer.