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目的 对奥美拉唑（ＯＭ）致低胃酸的人体与动物模型进行矿物质与微量元素（钙、磷、镁与锌） 吸收，以及血浆β胡萝卜素水平的研究。方法与结果 实验一（ 全胃肠道灌洗吸收法） 表明，健康成人口服ＯＭ（４０ｍｇ／ｄ，共９ 天），及给以外源性盐酸（０ ．１ Ｍ，１２０ｍｌ） 后，均不影响食物中矿物质的吸收；实验二发现，口服ＯＭ（４０ｍｇ，每日２ 次，共９ 天） 后，人体血清中总的β胡萝卜素水平升高反应低于对照组；实验三提示，上述ＯＭ 剂量致低胃酸时，小肠细菌过度生长，但细菌并未与β胡萝卜素结合而干扰其肠内吸收；实验四表明，ＯＭ 诱致低胃酸并不影响大鼠肠道锌吸收。结论 这些实验结果提示膳食中的Ｈ＋ 可能具有代偿低胃酸对营养素吸收影响的作用。
OBJECTIVE To study the absorption of minerals and trace elements (calcium, phosphorus, magnesium and zinc) in human and animal models of omeprazole-induced hypoglycemia, and to study the plasma levels of β-carotene. Methods and Results Experiment 1 (total gastrointestinal lavage absorption method) showed that OM (40 mg / d for 9 days) and exogenous hydrochloric acid (0.1 M, 120 ml) were not affected by OM In the second experiment, it was found that the increase of total β-carotene level in human serum was lower than that of the control group after oral administration of OM (40mg twice daily for 9 days). Experiment 3 suggested that the above mentioned OM dose hypoglycemic, intestinal bacterial overgrowth, but the bacteria did not combine with β-carotene and interfere with its intestinal absorption; Experiment IV showed that OM induced low gastric acid does not affect intestinal zinc absorption in rats. Conclusions These results suggest that dietary H + may have a compensatory effect on the absorption of nutrients by hypoacidic acids.