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方法：大鼠分别饲以低硒和补硒饲料３０天，补加油类之后（５０ｇ／ｋｇ饲料）继续饲养３０天。结果：线粒体膜磷脂中脂肪酸组成可反映大鼠饮食中脂肪酸的组成，磷脂酰胆碱（ＰＣ）和磷脂酰乙醇胺（ＰＥ）中Ｃ２０∶５和Ｃ２２∶６含量鱼油组明显高于豆油组，而且鱼油中Ｃ２２∶６比Ｃ２０∶５优先结合掺入磷脂中。ＰＣ中Ｃ２０∶４豆油组明显高于鱼油组。ω６／ω３比值降低。豆油和鱼油均使线粒体Ｃａ２＋－ＡＴＰａｓｅ活性下降，但对线粒体钙有不同的影响。补硒对脂肪酸组成，Ｃａ２＋－ＡＴＰａｓｅ影响不大，但加速钙的释放。结论：鱼油具有防治心血管疾病的作用，其作用基础可能在于Ｃ２０∶５和Ｃ２２∶６掺入细胞膜磷脂中，影响了脂肪酸组成，并对其功能产生影响
Methods: Rats were fed with low-selenium and selenium-supplemented feed for 30 days respectively, and the animals were fed for additional 30 days after oil supplementation (50g / kg feed). Results: The fatty acid composition of mitochondrial membrane phospholipid could reflect the fatty acid composition of rat diet. The contents of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) in C20: 5 and C22: 6 fish oil group were significantly higher than those in soybean oil group C22: 6 in fish oil is more preferentially incorporated into phospholipids than C20: 5. PC C20: 4 soybean oil group was significantly higher than the fish oil group. ω6 / ω3 ratio decreased. Both soybean oil and fish oil decreased mitochondrial Ca2 + -ATPase activity but had different effects on mitochondrial calcium. Selenium on fatty acid composition, Ca2 + -ATPase little effect, but to speed up the release of calcium. CONCLUSIONS: Fish oil has the effect of preventing and treating cardiovascular diseases. The basis of its action may lie in the incorporation of C20: 5 and C22: 6 into cell membrane phospholipids, affecting the fatty acid composition and affecting its function