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目的:探讨CD133在结肠直肠癌病人肿瘤组织中的表达及其与临床病理指标的关系。方法:采用免疫组化法检测83例结肠直肠癌病人的肿瘤组织与癌旁正常组织中CD133的表达,分析其与临床病理指标的相关性。结果:与癌旁正常组织相比,结肠直肠癌组织表达较高水平的CD133。CD133的高表达与肿瘤病理低分化、淋巴结转移等因素密切相关(P<0.05),而与病人年龄、性别、病理分期及病理类型无关(P>0.05)。结论:CD133在结肠直肠癌病人的肿瘤组织中表达显著升高,并与肿瘤的低分化、淋巴结转移密切相关。
Objective: To investigate the expression of CD133 in colorectal cancer patients and its relationship with clinicopathological parameters. Methods: Immunohistochemistry was used to detect the expression of CD133 in 83 cases of colorectal cancer and its adjacent normal tissues. The correlation between the expression of CD133 and clinicopathological parameters was analyzed. Results: Colorectal cancer tissues expressed higher levels of CD133 than normal tissues adjacent to the cancer. The high expression of CD133 was closely related to tumor pathological hypodifferentiation and lymph node metastasis (P<0.05), but not to the age, gender, pathological stage and pathological type of the patient (P>0.05). Conclusion: The expression of CD133 in colorectal cancer patients was significantly increased, and it was closely related to the poor differentiation and lymph node metastasis.