论文部分内容阅读
目的:观察桐油对糖尿病大鼠血糖、血脂及肝肾功能的影响。方法:45只SD雄性大鼠,随机选取10只为正常组,余下的35只采用链脲佐菌素(35 mg·kg~(-1))一次性腹腔注射方法制作糖尿病大鼠模型。2周后,将血糖升高的大鼠随机分为模型组、桐油高剂量组、桐油低剂量组,每组10只,高脂饲料喂养。在给药7周、11周末,观察桐油对大鼠空腹血糖(FPG)、血胆固醇(TC)、甘油三酯(TG)、肝脏谷丙转氨酶(GPT)、谷草转氨酶(GOT)及血尿素氮(BUN)、肌酐(Cr)的影响。结果:与模型组相比,桐油组FPG显著降低,具有统计学差异(P<0.001或P<0.05),对血脂的影响不显著。与正常组相比,桐油组GPT、GOT、BUN、Cr值均出现了异常升高,表明桐油对大鼠的肝、肾功能均有毒性作用。结论:桐油中的药效成分桐酸可能是发挥降血糖作用的主要物质基础,并具有潜在的肝肾毒性。
Objective: To observe the effects of tung oil on blood glucose, blood lipid and liver and kidney function in diabetic rats. Methods: Forty five male Sprague-Dawley rats were randomly selected as the normal control group and the remaining 35 diabetic rats were given a one-time intraperitoneal injection of streptozotocin (35 mg · kg -1). Two weeks later, the rats with hyperglycemia were randomly divided into model group, high-dose tung oil group and low-dose tung oil group, 10 rats in each group were fed with high fat diet. The effects of tung oil on fasting blood glucose (FPG), blood cholesterol (TC), triglyceride (TG), hepatic GPT, GOT and blood urea nitrogen (BUN), creatinine (Cr). Results: Compared with the model group, the FPG in the tung oil group was significantly lower (P <0.001 or P <0.05), and had no significant effect on the blood lipids. Compared with the normal group, there was an abnormal increase of GPT, GOT, BUN and Cr in the tung oil group, indicating that the tung oil had a toxic effect on the liver and kidney function in rats. CONCLUSION: Ectoic acid, an effective component of tung oil, may be the main material basis for its hypoglycemic effect and has potential hepatotoxicity.