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目的探讨心肌肌钙蛋白(c Tn I)在三氧化二砷(AS2O3)致心肌损害诊断中的意义。方法 40例初治的急性早幼粒细胞白血病(APL)患者,均给予AS2O3诱导缓解治疗。分别在治疗前、开始治疗后1周、2周、3周检测c Tn I水平,同时动态观察心电图变化。结果 35%患者在治疗后一周发生心电图改变,50.5%患者在治疗后第1周、第2周c Tn I升高,第3周下降。结论血清c Tn I检测能提高AS2O3致心肌损害的检出率,可作为一种特异性标志物。
Objective To investigate the significance of cardiac troponin (cTn I) in the diagnosis of myocardial damage induced by As 2 O 3. Methods Forty patients with newly diagnosed acute promyelocytic leukemia (APL) were given AS2O3 induction remission therapy. The levels of cTnI were measured before treatment and 1 week, 2 weeks and 3 weeks after the start of treatment, respectively. Meanwhile, the changes of electrocardiogram were observed dynamically. Results Electrocardiographic changes occurred in 35% of the patients one week after treatment, cTn I increased in the first week and the second week in 50.5% of the patients, and decreased in the third week. Conclusion The detection of serum cTnI can improve the detection rate of myocardial damage induced by AS2O3, which can be used as a specific marker.