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目的观察p27在不同病理类型胃癌组织中表达情况及其在胃癌发生中的作用。方法应用SP法检测p27在135例胃癌组织及45例正常胃黏膜组织中表达情况,其中高、中分化腺癌55例,低分化腺癌53例,黏液癌27例。结果胃癌组p27阳性表达率(45.93%)低于对照组(84.44%);胃高、中分化腺癌p27阳性表达率(65.45%)高于胃低分化腺癌(33.96%)和黏液癌(40.74%)(P均<0.05),胃低分化腺癌与黏液癌间p27阳性表达率差异无统计学意义(P>0.05);无淋巴结转移者胃癌组织中p27阳性表达率(48.00%)明显高于有淋巴结转移者(22.50%)(P<0.05);术后生存期≥5a者胃癌组织中p27阳性表达率(52.63%)高于术后生存期<5a者(16.67%)(P<0.05)。结论 p27在胃癌中的低表达可能与胃癌的发生、恶性程度、淋巴结转移及生存期有关;检测胃癌组织中p27的表达有助于判断肿瘤进展及预后。
Objective To observe the expression of p27 in different pathological types of gastric carcinoma and its role in gastric carcinogenesis. Methods The expression of p27 was detected in 135 cases of gastric carcinoma and 45 cases of normal gastric mucosa by SP method. Among them, 55 cases were high and moderately differentiated adenocarcinoma, 53 cases were poorly differentiated adenocarcinoma and 27 cases were mucinous carcinoma. Results The positive expression rate of p27 in gastric cancer group was lower than that in control group (45.93% vs 84.44%). The positive rate of p27 expression in gastric adenocarcinoma was higher than that in poorly differentiated adenocarcinoma (33.96%) and mucinous carcinoma 40.74%) (P <0.05). There was no significant difference in p27 expression between poorly differentiated adenocarcinoma and mucinous carcinoma (P> 0.05). The positive rate of p27 in gastric carcinoma without lymph node metastasis (48.00%) was significantly (P <0.05). The positive rate of p27 expression in gastric cancer tissues with a survival time of more than 5 years (52.63%) was significantly higher than that of those with lymph node metastasis (< 0.05). Conclusion The low expression of p27 in gastric cancer may be related to the occurrence of gastric cancer, the degree of malignancy, lymph node metastasis and survival. Detecting the expression of p27 in gastric cancer will help to judge the tumor progression and prognosis.