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The sub-healthy state, referred to a functional change without organic pathological process, and also called a third state or a gray state, or the inconstantly described syndromes with subjective discomfort symptoms and psychological experiences, is a transitional stage between the health and illness. In 2003-2004, the author used acupuncture and He-Ne laser vascular irradiation to regulate 30 cases of sub-healthy state. The report is as follows.