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近年研究提示,免疫细胞及肾小球细胞产生的细胞因子积极参与了肾炎病变。本文主要围绕IL-1,IL-2,IL-6,TNF 综述了细胞因子对肾小球细胞的体外效应,它们与肾炎发生、发展、预后的关系。表明在不同类型肾炎中,有不同细胞因子起主导作用,其中肾炎肾小球细胞因子自分泌途径的形成,促使肾小球成为“自毁式”靶器官。文章还围绕细胞因子探讨了肾炎发病机制。作者认为对细胞因子在肾炎中的作用的深入研究具有重要意义。
Recent studies suggest that immune cells and glomerular cells produced by cytokines actively involved in the nephritis lesions. In this paper, the effects of cytokines on glomerular cells in vitro and their relationship with the occurrence, development and prognosis of glomerulonephritis were reviewed mainly around IL-1, IL-2, IL-6 and TNF. It shows that different types of nephritis, different cytokines play a leading role, including glomerular nephritis cytokine autocrine pathway formation, promote glomerular become “self-destruction” target organ. The article also discusses the pathogenesis of nephritis around cytokines. The authors believe that the in-depth study of the role of cytokines in nephritis is of great importance.