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精原细胞瘤病人口服N[C~(14)]-甲酰溶肉瘤素15毫克(约30微居里)后72小时内,C~(14)自尿及大便的总排出量为剂量的68.0-77.4％;其中由尿及大便所排出的放射性各约半量.尿中的放射性绝大部分为给药后前5小时内排出的,大便中的放射性则主要在给药后48小时(两次大便,便秘患者除外)内排出.在服药后24小时内,血液(全血、血浆及血球)、唾液及呼出的二氧化碳仅有痕迹量放射性存在.口服N-甲C~(14)的同时,口服大量非标记的N-甲,并未显著地影响C~(14)的排泄.
Within 72 hours after oral administration of 15 mg of N [C14] -formylcysaritin in patients with seminoma, the total amount of C14 released from the urine and stool was dose 68.0-77.4%, of which about half of the radioactivity excreted by urine and feces were excreted. Most of the radioactivity in urine was excreted in the first 5 hours after administration, and the radioactivity in stool was mainly 48 hours after administration Stool, constipation patients excluded.) Within 24 hours after taking the medication, blood (whole blood, plasma and blood cells), saliva and exhaled carbon dioxide only traces of radioactive presence of oral N-methyl C (14) at the same time , Oral administration of a large number of non-labeled N-methyl, did not significantly affect the excretion of C ~ (14).