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本实验显示高三尖杉酯碱能在>5μg/ml浓度以上抑制兔红细胞膜上钙调蛋白活性(P<0.05).推测高三尖杉酯碱能通过影响癌细胞钙调蛋白活性干扰细胞钙代谢和减少阿霉素和长春新碱的抗药性.
This experiment showed that homoharringtonine can inhibit the calmodulin activity on rabbit erythrocyte membranes above the concentration of >5μg/ml (P<0.05). It is speculated that homoharringtonine can interfere with the calcium metabolism of cells by affecting the calmodulin activity of cancer cells. And reduce the resistance of doxorubicin and vincristine.