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本文对14007例使用头孢唑肟后出现毒副反应情况进行了分析。14007例病人中,7805例是门诊病人。5026例为成人(36%);959例为小于12岁的儿童(7%);8022例是大于65岁的老年人。其中12097例病人因不同部位感染而接受头孢唑肟治疗(耳鼻喉科623例、呼吸道9121例,泌尿道1870例及其它部位483例);1910例接受外科预防性治疗。头孢唑肟分别采用肌注(80%)或静注(20%),剂量为1～4g/d。全部病例中有118例出现不同程度的毒副作用(0.8%),其中成人占43人,儿童占12人,老年人占63人,不同年龄组毒副反应的发生率分别为0.9%、1.3%和0.8%。主要毒副反应包括胃肠道反应(39.4%)、皮疹(29.7%)、腹泻(15.8%),个别病例丙氨酸转氨酶、天冬氨酸转氨酶血液尿素氮轻度异常。仅有0.2%的病人由于药物毒副反应而
In this paper, the use of ceftizoxime after 14007 cases of adverse reactions were analyzed. Of the 14,007 patients, 7805 were outpatients. 5026 cases were adults (36%); 959 cases were children (7%) less than 12 years old; and 8022 cases were elderly persons older than 65 years old. Among them, 12,097 patients received ceftizoxime (623 cases of otolaryngology, 9,121 cases of respiratory tract, 1870 cases of urinary tract and 483 cases of other sites) due to infection of different parts; 1910 cases received surgical prophylactic treatment. Ceftizoxime were intramuscular (80%) or intravenous (20%), the dose of 1 ~ 4g / d. In all cases, 118 cases showed different degrees of side effects (0.8%), of which 43 were adults, 12 were children and 63 were seniors. The incidence rates of side effects in different age groups were 0.9% and 1.3%, respectively And 0.8%. The main side effects include gastrointestinal reactions (39.4%), skin rash (29.7%), diarrhea (15.8%), and mild cases of alanine aminotransferase and aspartate aminotransferase blood urea nitrogen. Only 0.2% of patients due to drug side effects