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目的明确腹膜透析(PD)患者红细胞分布宽度(RDW)及其相关因素,为PD患者预后评估提供新的参考指标。方法以无锡市人民医院2013年4月至2015年4月收治的224例PD患者,进行回顾性分析。使用Pearson相关分析,计算RDW与患者实验室检查指标的相关性,并将存在相关性的因素纳入Logistic多因素回归分析,明确影响PD患者RDW的相关因素。结果 224例患者中,共有35例患者RDW超出正常范围,占15.6%。男性与女性、急性感染患者与无急性感染患者RDW比较,差异无统计学意义(P>0.05)。Pearson相关分析示,年龄、Ln BNP、Ln CRP与患者RDW呈正相关,MCH、ALB、r Hu EPO/Hb与患者RDW呈负相关,差异有统计学意义(P<0.05)。多因素回归分析结果示,MCH、年龄、Ln BNP是影响PD患者RDW的独立危险因素,差异有统计学意义(P<0.05)。结论PD患者RDW异常较为常见,随着MCH的下降以及年龄、Ln BNP的增加,患者RDW逐渐升高。根据RDW水平变化有望指导患者疾病严重程度及PD效果的评估,但其确切临床价值有待进一步研究。
Objective To determine the distribution width of red blood cells (RDW) in patients with peritoneal dialysis (PD) and its related factors, and to provide a new reference index for the evaluation of PD patients. Methods A total of 224 PD patients admitted to Wuxi People’s Hospital from April 2013 to April 2015 were retrospectively analyzed. Pearson correlation analysis was used to calculate the correlation between RDW and laboratory tests. Logistic regression analysis was used to analyze the correlation between RDW and RDW. Results Of the 224 patients, a total of 35 patients had RDW outside the normal range, accounting for 15.6%. There was no significant difference in RDW between male and female patients with acute infection and those without acute infection (P> 0.05). Pearson correlation analysis showed that age, Ln BNP and Ln CRP were positively correlated with patients ’RDW. MCH, ALB and r Hu EPO / Hb were negatively correlated with patients’ RDW (P <0.05). Multivariate regression analysis showed that MCH, age, and Ln BNP were independent risk factors affecting RDW in patients with PD, the difference was statistically significant (P <0.05). Conclusions The abnormal RDW in PD patients is more common. With the decrease of MCH and the increase of age and Ln BNP, the RDW of patients gradually increases. According to changes in RDW level is expected to guide the patient’s disease severity and evaluation of PD effect, but its exact clinical value needs further study.