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目的:总结胃肠间质瘤(GIST)的临床病理和免疫组织化学(免疫组化)特征。方法:回顾性分析2008年1月至2013年10月间具完整临床资料的85例胃肠道间质瘤患者病例资料。结果:85例GIST病例中,发生于胃部46例(54.1%),发生于小肠24例(28.2%),发生于结直肠7例(8.24%),发生于其他部位8例(9.41%)。CD117阳性率100%,CD34阳性率76.5%。85例患者均接受手术治疗。71例患者获随访,随访率83.5%,随访时间为2-60个月,平均24.5个月。85例患者中,术后发生复发转移5例,死亡2例。结论:GIST的确诊主要依靠病理及免疫组化,CD117是诊断GIST的重要标记物,手术完整切除肿瘤为治疗GIST的首选方法。
Objective: To summarize the clinicopathological and immunohistochemical features of gastrointestinal stromal tumors (GISTs). Methods: The clinical data of 85 cases of gastrointestinal stromal tumors with complete clinical data from January 2008 to October 2013 were retrospectively analyzed. RESULTS: Of the 85 GIST cases, 46 (54.1%) occurred in the stomach, 24 (28.2%) occurred in the small intestine, 7 (8.24%) occurred in the colorectum, 8 (9.41%) occurred in other sites, . CD117 positive rate of 100%, CD34 positive rate of 76.5%. All 85 patients underwent surgery. 71 patients were followed up, the follow-up rate was 83.5%, followed up for 2-60 months, an average of 24.5 months. Of the 85 patients, 5 had recurrence and metastasis and 2 died. Conclusions: The diagnosis of GIST mainly depends on the pathology and immunohistochemistry. CD117 is an important marker in the diagnosis of GIST. Surgical complete resection of the tumor is the first choice for the treatment of GIST.