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目的:探讨高压氧(HBO)辅助治疗2型糖尿病突发性耳聋的临床疗效。方法:选取2010年1月至2019年12月在中国人民解放军联勤保障部队第九○四医院常州医疗区高压氧治疗中心就诊的80例2型糖尿病突发性耳聋患者作为研究对象，按随机数字表法分为观察组和对照组，每组40例。对照组接受糖皮质激素、扩容、扩血管及营养神经等治疗，观察组在对照组治疗的基础上予以HBO辅助治疗。治疗3个疗程后，比较2组患者的临床疗效、听力、血糖、炎性因子及应激指标、不良反应及并发症发生情况。结果:治疗3个疗程后，观察组总有效率(80.0%)明显高于对照组(57.5%)，差异有统计学意义(n P<0.05)。2组患者治疗后纯音听阈均较治疗前明显降低，且观察组纯音听阈低于对照组，差异均有统计学意义(n P<0.05)；观察组患者治疗后听阈增益明显高于对照组，差异有统计学意义(n P<0.05)。治疗3个疗程后，2组患者血清C-反应蛋白水平较本组治疗前明显降低，血清一氧化氮(NO)、一氧化氮合成酶(NOS)较本组治疗前均明显升高(n P<0.05)；观察组患者治疗后C-反应蛋白水平明显低于对照组，观察组患者治疗后NO、NOS水平明显高于对照组，差异均有统计学意义(n P<0.05)。观察组每个疗程结束后，血糖水平均明显低于对照组(n P<0.05)；观察组第3个疗程结束后血糖水平明显低于第1个疗程(n P0.05)。n 结论:HBO辅助治疗2型糖尿病突发性耳聋可降低患者炎性反应和应激反应，降低血糖水平，提高临床治疗效果，且安全性高，可临床推广应用。“,”Objective:To observe the effect of hyperbaric oxygen(HBO) in the treatment of sudden deafness for the patients with type 2 diabetes.Methods:A total of 80 patients with sudden deafness due to type 2 diabetes treated at the No.904 Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army from January 2010 to December 2019 were selected and divided into observation group (40 cases) and control group (40 cases) according to the random number table method. The control group received glucocorticoids, volume expansion, vascular dilation, and nerve nutrition therapies. The observation group was given HBO therapy on the basis of the treatment of the control group. The efficacy, hearing, blood glucose, inflammation factor, stress indicators, adverse reactions, and complications of the two groups after 3 courses of treatment were observed.Results:After 3 courses of treatment, the total effective rate of the observation group (80.0%) was higher than that of the control group (57.5%), and the difference was statistically significant (n P<0.05). After treatment, the pure tone hearing thresholds of both groups were lower than that before the treatment; the pure tone hearing threshold of the observation group was lower than that of the control group(n P<0.05). After treatment, the hearing threshold gain of the observation group was significantly larger than that of the control group (n P<0.05). After 3 courses of treatment, within each group, C-reactive protein was obviously lower than before, while the levels of nitric oxide (NO) and nitric oxide synthesis rate-limiting enzyme (NOS) were all significantly higher than before (n P<0.05). After treatment, C-reactive protein of the observation group was remarkably lower than that of the control group, and the levels of NO and NOS in the observation group were significantly higher than those in the control group (n P<0.05). After each course of treatment, the levels of blood glucose in the observation group was lower than that in the control group (n P<0.05). In the observation group, the level of blood glucose after the third course of treatment was obviously lower than that after the first course of treatment, and the difference was statistically significant (n P0.05).n Conclusion:HBO as an auxiliary treatment for the sudden deafness patients due to type 2 diabetes can reduce the inflammatory response and stress response, reduce blood glucose level, improve the clinical efficacy and has high safety, which is worth of clinical application.