Quinimax直肠给药与静脉推注给药治疗尼日尔儿童脑型疟的随机对比临床研究

• 作 者: 陶奕
• 出 处: 国外医学(寄生虫病分册)
• 发表日期: 1999年04期
• 关键词: 直肠给药 Quinimax 静脉推注给药 脑型疟 药物动力学 蒿甲醚 鼻腔给药 给药途径 脑型恶性疟 药物浓度

在尼日尔医院,凶险型脑型疟的死亡率达26％。奎宁仍是目前治疗重症疟疾的最有效的药物。由于设备和有经验医务人员的缺乏以及给药途径不同等原因,无论静注、肌注、鼻腔给药还是口服的疗效都还不够理想。直肠给药作为替换的方法正引起重视,药物动力学和治疗学研究均已表明蒿甲醚及氯喹的直肠给药是一种安全有效的疟疾治疗新途径。为此,作者用Quinmax(每100mg/ml含奎宁基质59.3mg)通过直肠给药与静脉推

In Niger hospital, the death rate of dangerous cerebral malaria reached 26%. Quinine is still the most effective drug currently used to treat severe malaria. Due to the lack of equipment and experienced medical staff and different routes of administration, the efficacy of intravenous, intramuscular, intranasal or oral administration is not satisfactory. Rectal administration is gaining attention as an alternative method. Pharmacokinetics and therapeutic studies have shown that rectal administration of artemether and chloroquine is a safe and effective new approach to malaria treatment. To this end, the authors used Quinmax (quinine base per 100mg / ml 59.3mg) by rectal and intravenous push