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心肌内膜活检(EMB)已成为成人心脏病的一种常规诊断方法。广泛用于心脏移植、心肌病、心肌炎、心脏毒性化疗等的研究中。但在婴儿和儿童中的应用报道较少。本文介绍了作者对60例婴儿和儿童 EMB 的经验。病例和方法60例患儿(男35例、女25例),年龄1个月～22岁(平均3.5岁),其中小于15岁56例;体重在3～67kg(平均12.6kg)。在镇静但未麻醉的状态下,采用薄壁 6-F 聚四氟乙烯端孔导管,经静脉进入右室,经卵园孔或逆行途径进入左室,活检器经导引管插入。每例取材1～5块,经2%戊二醛固定后,用光学显微镜和电子显微镜检查。组织学检查结果的临床评价如下:(1)确定诊断:即组织学发现
Endomyocardial biopsy (EMB) has become a routine diagnostic method for adult heart disease. Widely used in heart transplantation, cardiomyopathy, myocarditis, cardiotoxic chemotherapy and other research. However, the application in infants and children is rarely reported. This article presents the authors’ experience with EMB in 60 infants and children. Cases and Methods Sixty children (35 males and 25 females) aged 1 month to 22 years (average 3.5 years), of whom 56 were less than 15 years old and weighing 3-67 kg (average 12.6 kg). In a calm but not anesthetized condition, a thin-walled 6-F Teflon ported catheter was introduced into the right ventricle through the vein and into the left ventricle through the oval hole or retrograde approach. The biopsy was inserted through the guide tube. Each sample taken 1 to 5, after fixation with 2% glutaraldehyde, with light microscopy and electron microscopy. Clinical evaluation of histological findings are as follows: (1) to determine the diagnosis: that histological findings