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目的 研究高胆固醇血症与糖尿病肾病的关系。方法 将 90例 2型糖尿病患者 ,依据病情程度分组。同时测定糖尿病各组与正常对照组的血胆固醇、空腹血糖、糖化血红蛋白、肌酐、尿白蛋白排出率、内生肌酐清除率 ,分析胆固醇与空腹血糖、糖化血红蛋白、肝酐、尿白蛋白排出率与内生胆酐清除率的相关性。结果 高胆固醇血症与糖化血红蛋白、肌酐、尿白蛋白排出率分别呈正相关、与内生肌酐清除率呈负相关。结论 高胆固醇血症与糖尿病肾病有相关性 ,高胆固醇血症是糖尿病肾病的危险因素 ,降血胆固醇治疗可防治及延缓糖尿病肾病。
Objective To study the relationship between hypercholesterolemia and diabetic nephropathy. Methods Ninety patients with type 2 diabetes were divided into groups according to the severity of the disease. Blood cholesterol, fasting blood glucose, glycosylated hemoglobin, creatinine, urinary albumin excretion rate and endogenous creatinine clearance rate in each group and normal control group were also measured, and cholesterol and fasting blood glucose, glycated hemoglobin, hepatic anhydride and urinary albumin excretion rate Correlation with endogenous cholinesterase clearance. Results Hypercholesterolemia and glycated hemoglobin, creatinine, urinary albumin excretion rate were positively correlated, and endogenous creatinine clearance was negatively correlated. Conclusions Hypercholesterolemia is associated with diabetic nephropathy. Hypercholesterolemia is a risk factor for diabetic nephropathy. Hypocholesterolemia can prevent and delay diabetic nephropathy.