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目的探讨博尔纳病病毒(BDV)感染与神经胶质瘤发生的可能相关性。方法用Western-blot方法,对23例神经胶质瘤患者和23例脑外伤患者血清中BDV-p24/p40特异性抗体进行检测。结果 23例神经胶质瘤患者血清中BDV-p24/p40抗体阳性4例,阳性率为17.4%;脑外伤患者血清标本中无BDV-p40抗体检出,阳性率为0%。结论神经胶质瘤患者血清中存在博尔纳病病毒的感染。
Objective To investigate the possible relationship between Borna disease virus (BDV) infection and the occurrence of glioma. Methods Serum BDV-p24 / p40 specific antibodies in 23 patients with glioma and 23 patients with traumatic brain injury were detected by Western-blot. Results Serum BDV-p24 / p40 antibody was positive in 4 of 23 patients with glioma, the positive rate was 17.4%. No BDV-p40 antibody was detected in sera of patients with traumatic brain injury, the positive rate was 0%. Conclusions The presence of Borna disease virus in the serum of glioma patients.