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目的观察抗结核性药物所致肝损害患者的临床特点,总结其预防和治疗措施。方法对湖南省娄底市中心医院2008年4月至2010年4月210例抗结核治疗患者的肝功能损害情况进行回顾性分析。结果 210例患者在治疗过程中有164例出现不同程度的肝功能损害。轻度损害者加用保肝治疗患者肝功能可恢复正常,中、重度患者经改用或停用肝毒性药物并加保肝治疗,大部分患者肝功能可恢复,但有部分患者肝功能进行性恶化,导致抗结核治疗终止。结论加强对抗结核治疗患者肝功能损伤的观察并在早期加以保肝治疗是保证抗结核治疗顺利完成的重要措施。
Objective To observe the clinical features of patients with liver damage caused by anti-tuberculosis drugs and summarize their preventive and therapeutic measures. Methods Retrospective analysis was performed on 210 patients with anti-TB treatment of liver dysfunction from April 2008 to April 2010 in Loudi Central Hospital of Hunan Province. Results In the 210 patients, 164 cases showed different degrees of liver damage during the course of treatment. Mild damage plus liver treatment patients with liver function can be restored to normal, moderate and severe patients by switching or switching off hepatotoxic drugs and liver protection, most patients with liver function can be restored, but some patients with liver function Sexual deterioration, leading to the termination of anti-TB treatment. Conclusions Strengthening the observation of liver function injury in patients with anti-tuberculosis treatment and protecting liver in early stage are important measures to ensure successful completion of anti-TB treatment.