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目的探讨三亚地区酒精性肝病(ALD)的临床特征,为提高早期诊断及治疗提供科学依据。方法对2010年3月~2013年10月收治的62例酒精性肝病患者的临床资料进行回顾性分析。结果 62例ALD,按2010年1月修订的酒精性肝病治疗指南分为酒精性脂肪肝13例,酒精性肝炎20例,酒精性肝硬化29例。平均饮酒年限为(17.7±7.6)年,平均每日饮酒量为(164.1±31.2)g,主要临床表现主要为食欲减退53例,占85.2%,肝肿大41例,占65.6%、黏膜出血22例,占35.1%,患者血清AST、ALT、GGT、TBiL的异常率分别为82.3%(51/62)、(78.5%(49/62)、85.6%(53/62)、68.5.3%(43/62)。经2周的治疗,消化道出血情况全部得到纠正,B超示近场回声弥漫性增加,远场回声逐渐衰减较治疗前明显减轻,肿大的肝脏明显回缩,没有死亡病例。结论长期、大量、多种类混合饮酒易引发ALD。因此,宣传健康生活方式、加强ALD知识的宣传教育,按期进行健康体检,以早发现ALD并早治疗。
Objective To explore the clinical features of alcoholic liver disease (ALD) in Sanya area and provide a scientific basis for improving early diagnosis and treatment. Methods The clinical data of 62 patients with alcoholic liver disease admitted from March 2010 to October 2013 were analyzed retrospectively. Results Sixty two patients with ALD were divided into alcoholic fatty liver (13 cases), alcoholic hepatitis (20 cases) and alcoholic cirrhosis (29 cases) according to the revised guideline of alcoholic liver disease in January of 2010. The average duration of alcohol drinking was (17.7 ± 7.6) years. The average daily drinking amount was (164.1 ± 31.2) g. The main clinical manifestations were mainly appetite loss in 53 cases (85.2%), hepatomegaly in 41 cases (65.6%), mucosal bleeding 22 cases, accounting for 35.1%. The abnormal rates of AST, ALT, GGT and TBiL were 82.3% (51/62), 78.5% (49/62), 85.6% (53/62) and 68.5% (43/62) after 2 weeks of treatment, gastrointestinal bleeding were all corrected, B-ultrasound showed diffuse increased near-field echo, far-field echo attenuation was significantly reduced compared with before treatment, the enlarged liver was significantly retracted, no Fatal cases.Conclusion Long-term, large-scale and multi-types of mixed drinking lead to ALD easily.Therefore, publicizing healthy lifestyles, strengthening the publicity and education of ALD knowledge, conducting regular physical examination on schedule, early detection and early treatment of ALD.