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目的探讨米索前列醇不同的给药途径对预防产后出血的临床效果及应用价值。方法回顾性分析96例正常足月妊娠阴道分娩产妇的一般资料,按照随机、对照的原则分为观察组和对照组,各为48例。观察组将米索前列醇600μg分别置于产妇阴道后弯窿或直肠壁下1/3处,用手按压2 m in左右使之溶解,对照组则于宫缩间歇时一次口服或舌下含服。比较和分析两组产妇产后2 h和24 h出血量及用药后不良反应。结果观察组产后2 h和24 h出血量明显低于对照组,两组比较差异具有统计学意义(P<0.05);用药后,观察组出现2例不良反应,占4.2%,对照组出现9例不良反应,占18.75%,两组比较差异有统计学意义(P<0.05)。结论米索前列醇预防产后出血的用药途径宜采用阴道、直肠给药,临床效果显著,给药方便,不良反应较小,值得临床进一步推广应用。
Objective To investigate the clinical effects and application value of different administration routes of misoprostol in preventing postpartum hemorrhage. Methods A retrospective analysis of 96 cases of normal term vaginal delivery of maternal general information, according to the principle of randomized, control were divided into observation group and control group, each of 48 cases. The observation group will misoprostol 600μg were placed in the maternal vaginal bend or rectal wall 1/3, hand press 2 m in about to dissolve the control group contractions in the contractions of a time oral or sublingual clothes. Comparison and analysis of the two groups of postpartum 2 h and 24 h postpartum hemorrhage and adverse reactions after treatment. Results The bleeding volume of observation group 2 h and 24 h postpartum was significantly lower than that of the control group, the difference between the two groups was statistically significant (P <0.05); after treatment, there were 2 adverse reactions in the observation group, accounting for 4.2%, while the control group 9 Cases of adverse reactions, accounting for 18.75%, the difference between the two groups was statistically significant (P <0.05). Conclusion Misoprostol to prevent postpartum hemorrhage route should adopt vaginal and rectal administration, the clinical effect is significant, convenient administration, adverse reactions smaller, it is worth further clinical application.