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溶栓治疗是当前公认的可快速恢复血流、挽救可逆性损伤状态脑细胞，治疗急性缺血性脑卒中的有效治疗方法之一。超早期（3 h内）重组组织型纤溶酶原激活剂溶栓治疗的安全性、有效性已得到广泛认可，但由于国内医疗资源的限制，众多患者无法在治疗时间窗内得到有效的治疗。现就溶栓的作用机制、治疗时间窗，扩大时间窗常用的方法和疗效以及溶栓的并发症进行总结，以期有更多的患者从溶栓治疗中获益。“,”Currently,thrombolytic therapy is universally considered as one of the effective treatments to quickly recover blood flow,save brain cells in the reversible damage state and treat acute ischemic stroke .The security and effectiveness of ultra-early ( within three hours) rt-PA thrombolytic therapy has been widely rec-ognized,but due to the restriction of domestic medical resources,numerous patients fail to get effective treat-ment in the therapeutic time window.This article reviews the mechanism of thrumbolytic,time of therapy,the general′s method and efficacy of extending time window ,thrombolytic′s complications,in order to make more patients benefit from rt-PA thrombolytic therapy.