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有假说认为并发肾病的１型糖尿病患者可因有ＴＧＦ－β１生成过多的遗传倾向而易患肾病。为了验证这一假说,作者对并发或没有并发肾病的１型糖尿病患者的外周血单个核细胞(ＰＢＭＣ)ＴＧＦ－β１分泌进行了研究。方法 共研究５２例,根据研究前夜收集的３次尿液白蛋白中位数排泄率分成３组。计有
Patients with type 1 diabetes who are hypothesized to have concurrent kidney disease may be predisposed to kidney disease due to an overly genetic predisposition to TGF-β1. To test this hypothesis, the authors investigated the secretion of TGF-β1 from peripheral blood mononuclear cells (PBMCs) in patients with type 1 diabetes mellitus with or without concurrent renal disease. Methods A total of 52 cases were studied. According to the urinary albumin excretion rates of the three urinalysis collected on the eve of the study, the patients were divided into three groups. There are