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恶性淋巴瘤经放疗或化疗后发生急性非淋巴细胞白血病(ANLL)数目已有增加,然而结节性淋巴细胞淋巴瘤,从未接受过放疗和化疗的患者,随后发生ANLL,既往未有报道。本文1例结节性淋巴瘤,先前仅以白细胞干扰素治疗,结果成为ANLL,报告如下。患者男性,57岁,1979年11月发生弥漫性淋巴结病。淋巴结活检为结节性淋巴细胞分化不良型恶性淋巴瘤。双足淋巴管造影示副主动脉扩大。但骨髓活检阴性。分类属Ⅲ期。自同年11月28日至12月27日接受α干扰素肌注,剂量为300万U/d。干扰素从人黄层
There has been an increase in the number of acute non-lymphocytic leukemia (ANLL) in patients with malignant lymphomas after radiotherapy or chemotherapy. However, patients with nodular lymphocytic lymphomas, who have never received radiation and chemotherapy, have subsequently developed ANLL and have not previously been reported. This article, a case of nodular lymphoma, previously treated with leukocyte interferon, the results become ANLL, the report is as follows. The patient, male, 57 years old, developed diffuse lymphadenopathy in November 1979. Lymph node biopsy is poorly differentiated lymphoma with nodular lymphoid lymphoma. Pairs of lymphangiography showed aortic enlargement. However, bone marrow biopsy negative. Classification is phase Ⅲ. From November 28 to December 27 of the same year, IFN-α was intramuscularly injected at a dose of 3 million U / d. Interferon from human yellow layer