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目的探讨急性脑梗死与血浆同型半胱氨酸(Hey)关系及其临床意义。方法选取120例急性脑梗死住院患者和80例同年龄段健康体格检查人群进行血浆Hey、叶酸和维生素B12的测定,并进行比较。结果急性脑梗死组患者血浆Hcy水平明显升高(P<0.01),叶酸、维生素B12水平明显低于对照组(P<0.01)。结论急性脑梗死组患者血浆Hcy升高,而叶酸、维生素B12下降,可以认为同型半胱氨酸血症是急性脑梗死的独立危险因素。
Objective To investigate the relationship between acute cerebral infarction and plasma homocysteine (Hey) and its clinical significance. Methods A total of 120 inpatients with acute cerebral infarction and 80 healthy people at the same age were enrolled in this study. Plasma Hey, folic acid and vitamin B12 were measured and compared. Results Plasma Hcy levels in patients with acute cerebral infarction were significantly increased (P <0.01), and folic acid and vitamin B12 levels were significantly lower than those in the control group (P <0.01). Conclusions Patients with acute cerebral infarction have higher plasma Hcy and decreased folic acid and vitamin B12. Homocysteinemia may be regarded as an independent risk factor for acute cerebral infarction.