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目的:比较哌拉西林/他唑巴坦与头孢曲松治疗小儿细菌性肠炎的疗效。方法:176例细菌性肠炎患儿随机分为2组,观察组90例使用哌拉西林/他唑巴坦100 mg·kg~(-1)·d~(-1),ivd,bid;对照组86例使用头孢曲松50 mg·kg~(-1)·d~(-1),ivd,qd。两组均不用其他抗菌药,治疗5 d后观察疗效。结果:观察组和对照组有效率分别为85.56%和81.40%,细菌清除率分别为87.23%和84.44%,细菌耐药率分别为14.42%和19.23%,差异均无统计学意义(P>0.05)。结论:哌拉西林/他唑巴坦治疗小儿细菌性肠炎疗效与头孢曲松相近。
Objective: To compare the efficacy of piperacillin / tazobactam and ceftriaxone in the treatment of bacterial enteritis in children. Methods: One hundred and seventy-six children with bacterial enteritis were randomly divided into two groups. The observation group received piperacillin / tazobactam 100 mg · kg -1 · d -1, iv, In the 86 cases, ceftriaxone 50 mg · kg -1 · d -1, ivd, qd were used. No other antibacterials were used in both groups, and the effect was observed after 5 days of treatment. Results: The effective rates of the observation group and the control group were 85.56% and 81.40% respectively, the bacterial clearance rates were 87.23% and 84.44%, and the bacterial resistance rates were 14.42% and 19.23% respectively, with no significant difference (P> 0.05 ). Conclusion: The efficacy of piperacillin / tazobactam in treating children with bacterial enteritis is similar to ceftriaxone.