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心肌病的病因迄今仍不完全清楚,常见的病理改变为心室肥厚和广泛的瘢痕形成,并伴有不同程度的心室扩张。为了进一步研究其病因,作者观察了患有遗传性心肌病的叙利亚田鼠(Syrian hamster)。这种动物一般1月龄时即出现局灶性心肌坏死,随后出现瘢痕形成、心室壁肥厚和心室扩张。通常一年内导致充血性心衰(CHF),最终死亡。其病因不清。一些研究表明病鼠心肌Ca~(++)跨膜内流增加,导致心肌细胞收缩功能亢进、线粒体钙化和细
The etiology of cardiomyopathy is still not fully understood so far. Common pathological changes are ventricular hypertrophy and extensive scarring accompanied by varying degrees of ventricular dilatation. To further investigate its etiology, the authors looked at Syrian hamsters with hereditary cardiomyopathy. This animal typically presents with focal myocardial necrosis at 1 month of age, followed by scarring, ventricular wall hypertrophy and ventricular dilatation. Usually one year leads to congestive heart failure (CHF) and eventually dies. The cause is unclear. Some studies have shown that the increased transmembrane flux of Ca ~ (++) in the diseased myocardium results in hypertrophic cardiomyocyte contraction, mitochondrial calcification and fine