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在(一)-表没食子儿茶素(EGC)的3位导入不同长度的直链及分支脂肪酸,以增强脂溶性和改善体内动态,创制有效性高的抑癌物质。 方法:(一)-EGC的3位选择性导入直链或分支脂肪酸(C4～18)得到的衍生物,在抑制EBV初期抗原表达的试验中,与(一)-EGC、EGCG显示同等程度的抑制活性。对此,进行DMBA诱发ICR小鼠皮
In (a) - epigallocatechin (EGC) 3 into the introduction of different lengths of linear and branched-chain fatty acids to enhance fat-soluble and improve body dynamics, the creation of effective anti-cancer substances. Methods: (a) - Derivatives obtained by selective introduction of linear or branched fatty acids (C4-18) at the 3-position of EGC in the test for inhibiting the expression of EBV primary antigen showed the same degree as (I) -EGC and EGCG Inhibit activity For this, DMBA-induced ICR mouse skin was performed