A Facile Stereospecific Synthesis of 1, 3-Enynylsulfides via Sonogashira Coupling of (E)-α-Iodovinyl

• 作 者: Jian Wen JIANG Ming Zhong CAI
• 机 构: Department of Chemistry
• 出 处: 中国化学快报（英文版）
• 发表日期: 2004年期
• 关键词: (E)-α-Iodovinyl sulfide 1 3-enynylsulfide Sonogashira coupling terminal alkyne

(E)-α-Iodovinyl sulfides 1 underwent the Sonogashira coupling reactions with terminal alkynes 2 in piperidine at room temperature in the presence of 5 mol % of Pd(PPh3)4 and 10 mol %of CuI to afford the corresponding 1, 3-enynylsulfides 3 stereospecifically in high yields.