【摘 要】
：
A novel tungstosilicic polyoxometalate containing 5-fluorouracil and Nd,K26(C4H4FN2O2)8Nd(SiW11O39)4·SH2O(FNSW)was synthesized and its structure was characteri
【机 构】
：
College of Science,State Key Laboratory of Explosion Science and Technology
论文部分内容阅读
A novel tungstosilicic polyoxometalate containing 5-fluorouracil and Nd,K26(C4H4FN2O2)8Nd(SiW11O39)4·SH2O(FNSW)was synthesized and its structure was characterized by using elemental analysis,FT-IR spectra,X-ray powder diffraction,UV-vis spectra and TG.The results indicated that the compound FNSW had Keggin structure of heteropolyanion and ring structure of 5-fluorouracil,and it had a good thermal stability.With 5-fluorouracil for the positive control group,the cytotoxicity tests in human renal embryonic cell HEK293 and the antitumor activity tests in hepatocellular carcinoma cell HepG-2 were carried out by the methyl thiazolyl tetrazolium method.The toxicity of the compound FNSW was lower than that of 5-fluorouracil,and compared with 5-fluorouracil the compound FNSW could inhibit HepG-2cell in vitro with significant difference.The rare earth clement Nd increased the biological activity of polyoxometalate significantly.
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